Lazio have Ciro Immobile, Felipe Caicedo, Sergej Milinkovic-Savic and Luis Alberto in the starting XI of their Coppa Italia tie with Novara.
The Round of 16 match kicks off at the Stadio Olimpico at 14.00 GMT.
The winners of this one-off encounter will go on to face either Inter or Benevento in the quarter-final.
Danilo Cataldi, Alessandro Rossi and Stefan Radu are all suspended, with Dusan Basta and Martin Caceres left out awaiting a January transfer.
Joaquin Correa was a candidate to start, but has been ruled out completely by a flu virus, so Caicedo supports Immobile.
Milinkovic-Savic and Luis Alberto flesh out the midfield with Lucas Leiva now fully recovered from his injury.
Novara are minnows in this tournament, as they currently play in Serie C, but eliminated Perugia, Brescia and Pisa to reach the final 16.
They must do without suspended Angelo Tartaglia and Pablo Andres Gonzalez, injured Daniele Cacia, Tommaso Bianchi and Diego Peralta.
Lazio: Strakosha; Bastos, Luiz Felipe, Acerbi; Marusic, Milinkovic-Savic, Leiva, Luis Alberto, Lukaku; Caicedo, Immobile
Novara: Benedettini; Cinaglia, Chiosa, Bove, Visconti; Sciaudone, Ronaldo, Nardi; Schiavi; Manconi, Eusepi
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